Dialogues in Cardiovascular Medicine
is part of the continuing education programs
of the International Society for Heart Research,
of the European Society of Cardiology,
and of the Italian Society of Cardiology
This is made possible through
an unrestricted educational grant
from Servier
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Many aspects of cardiovascular physiology are subject
to diurnal variation, and serious adverse cardiovascular
events, including myocardial infarction, sudden
cardiac death, and stroke, occur with a frequency
conditioned by the time of day... |
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The molecular clock orchestrates
the circadian integration and organization
of many aspects of
physiology that correspond with
the duration of the rotation of the
earth on its axis, ie, 24 hours.
Circadian rhythms influence nearly
every important physiologic
process. The human cardiovascular
system and cardiovascular disease
are influenced by circadian
rhythms... |
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Daily fluctuations in the efficacy
and toxicity of drugs are thought to
reflect effects of the circadian clock
on disease severity, target organ sensitivity,
and the absorption, distribution,
metabolism, and excretion
(ADME) of drugs... |
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