International Society for Heart Research (ISHR) European Society of Cardiology SIC - Italian Society of Cardiology Dialogues in Cardiovascular Medicine is part of the continuing education programs of the International Society for Heart Research, of the European Society of Cardiology, and of the Italian Society of Cardiology

This is made possible through an unrestricted educational grant from Servier

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Many aspects of cardiovascular physiology are subject to diurnal variation, and serious adverse cardiovascular events, including myocardial infarction, sudden cardiac death, and stroke, occur with a frequency conditioned by the time of day...





The molecular clock orchestrates the circadian integration and organization of many aspects of physiology that correspond with the duration of the rotation of the earth on its axis, ie, 24 hours. Circadian rhythms influence nearly every important physiologic process. The human cardiovascular system and cardiovascular disease are influenced by circadian rhythms...





Daily fluctuations in the efficacy and toxicity of drugs are thought to reflect effects of the circadian clock on disease severity, target organ sensitivity, and the absorption, distribution, metabolism, and excretion (ADME) of drugs...









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