Despite important advances over the last two decades, heart disease remains a major cause of morbidity and mortality in Western society. As a result, in addition to optimizing existing approaches, new approaches are needed to treat heart disease. Agents which alter energy metabolism in the heart offer an exciting new approach to treating ischemic heart disease and other cardiovascular complications. A preponderance of experimental and clinical data now support the concept that shifting energy substrate preference away from fatty acid metabolism and towards glucose metabolism is a novel and effective approach to treating cardiovascular disease...