Reversibility of cardiac wall motion abnormalities predicted
by positron tomography
J. Tillisch, R. Brunken, R. Marshall, M. Schwaiger, M. Madelkorn, P. Phelps, H. Schelbert
This key, early clinical study from the UCLA
Medical Center was one of the first to
investigate whether the technique of positron
emission tomography (PET) can be used
to predict the metabolic viability of the
myocardium...
Dobutamine echocardiography in myocardial hibernation.
Optimal dose and accuracy in predicting recovery of ventricular
function after coronary angioplasty
I. Afridi, N.S. Kleiman, A.E. Raizer, W.A. Zoghbi
The aims of this prospective clinical study
were: (i) to investigate whether hearts that are
hibernating can be identified by dobutamine
echocardiography; and (ii) to determine
whether a dose-response curve for
dobutamine can improve the accuracy of the test...
Metabolic adaptation to a gradual reduction
in myocardial blood flow
A.E. Arai, S.E. Grauer, C.G. Anselone, G.A. Pantely, J.D. Bristow
Can the heart downregulate itself in response to
a gradual reduction of blood flow or are the
transient metabolic abnormalities, associated
with a sudden decrease in flow, necessary for
such adaptation?...
Enhanced detection of ischemic but viable myocardium
by the reinjection of thallium after stress redistribution imaging
V. Dilsizian, T.P. Rocco, N.M.T. Freedman, M.B. Leon, R.O. Bonow
Dilsizian and colleagues begin this clinical
paper by stressing the importance of
identifying patients with reversible left
ventricular dysfunction, ie, hibernating
myocardium, who, as a subgroup,
would benefit from revascularization...
Adaptive responses of coronary circulation and myocardium
to chronic reduction in perfusion pressure and flow
I. Mills, J.T. Fallon, D. Wrenn, H. Sasken, W. Gray, J. Bier, D. Levine, S. Berman, M. Gilson, H. Gewirtz
In this study pigs were used to investigate the
response of the myocardium and the coronary
circulation to chronic ischemia (of 4 to 32 weeks
duration)...
Ischemic cardiomyopathy: criteria for coronary revascularization
and cardiac transplantation
H.W. Louie, H. Laks, E. Milgalter, D.C. Drinkwater Jr, M.A. Hamilton, R.C.Brunken, L.W. Stevenson
Another clinical study from the UCLA School
of Medicine is described here, from the same
department as the paper by Tillisch et al
(see page 94)...
Echocardiography during infusion of dobutamine
for identification of reversible dysfunction in patients
with chronic coronary artery disease
G. La Canna, O. Alfieri, R. Giubbini, M. Gargano, R. Ferrari, O. Visioli
The aim of this prospective study from Italy
was to test whether the contractile response
to low-dose dobutamine was useful in the
detection of myocardial viability in patients
with coronary artery disease and left
ventricular (LV) dysfunction...
The hibernating myocardium
S.H. Rahimtoola
Rahimtoola, who is generally regarded as the
“father” of hibernation, begins this editorial
by giving a definition of the hibernating
myocardium...
Recruitment of an inotropic reserve in moderately ischemic
myocardium at the expense of metabolic recovery:
a model of short-term hibernation
R. Schulz, B.D. Guth, K. Pieper, C. Martin, G. Heusch
In this experimental study, Schulz et al use
open-chest minipigs to create a model of short-term
myocardial hibernation in order to characterize its
functional and metabolic status and to investigate
the effects of inotropic stimulation...
Metabolic adaptation during a sequence of no-flow
and low-flow ischemia: a possible trigger for hibernation
R. Ferrari, A. Cargnoni, P. Bernocchi, E. Pasini, S. Carello, C. Ceconi, T.J.C. Ruigrok
In this experimental study, Ferrari and colleagues
develop a protocol that mimics the clinical situation
that precedes the development of myocardial
hibernation; isolated, perfused hearts are subjected
to an initial period of total global ischemia prior to
an extended period of low-flow perfusion and a subsequent
period of reperfusion...
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