Generalized model of restenosis after conventional balloon angioplasty, stenting and directional atherectomy
Kuntz RE, Gibson CM, Nobuyoshi M, Baim DS

The demonstration that stenosis after angioplasty, minimal lumen diameter (MLD), or change in MLD are all continuous variables—and not divided into a bimodal population representing restenosis or no restenosis—produced a profound change in the thinking behind the restenosis process...

Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months
Topol EJ, Califf RM, Weisman HF, et al, on behalf of the EPIC Investigators

Numerous studies have used antiplatelet agents to prevent restenosis...

Restenosis after successful percutaneous transluminal coronary angioplasty: serial angiographic follow-up of 229 patients
Nobuyoshi M, Kimura T, Nosaka H, Mioka S, Ueno K, Yokoi H, Hamasaki N, Horiuchi H, Ohishi H

Angioplasty results in overexpansion of the vessel, with dissection of the intimal plaque, often extending into the media...

Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides
Bennett MR, Anglin S, McEwan JR, Jagoe R, Newby AC, Evan GI

The failure of conventional pharmacological agents to inhibit restenosis has spawned a whole series of studies dedicated to using gene therapy to prevent restenosis...

Lumen narrowing after percutaneous transluminal coronary balloon angioplasty follows a near-Gaussian distribution: a quantitative angiographic study in 1445 successfully dilated lesions
Rensing BJ, Hermans WRM, Deckers JW, de Feyter PJ, Tijssen JGP, Serruys PW

Clinical classifications of restenosis are based on a number of criteria; primarily, the patient has a return of symptoms, with demonstrable narrowing of the previously dilated vessel...

Proliferation in primary and restenotic coronary atherectomy tissue: implications for antiproliferative therapy
O’Brien ER, Alpers CE, Stewart DK, Ferguson M, Tran N, Gordon D, Benditt EP, Hinohara T, Simpson JB, Schwartz SM

For the last 20 years, vascular smooth muscle cell proliferation has been considered to be an indispensable part of the pathogenesis of atherosclerosis, and more recently, of angioplasty restenosis...

A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease
Fischman DL, Leon MB, Bairn DS, et al, for the STent REStenosis Study Investigators

Restenosis following angioplasty has been the Achilles’ heel of the technique since its inception...

A comparison of directional atherectomy with coronary angioplasty in patients with coronary artery disease
Topol EJ, Leya F, Pinkerton CA, et al, for the CAVEAT Study Group

The high rate of restenosis following balloon angioplasty has acted as a driving force for the development of a number of different interventions in an attempt to improve overall long-term patency rates...

Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study
Mintz GS, Popma JJ, Pichard AD, Kent KM, Satler LF, Wong SC, Hong MK, Kovach JA, Leon MB

The emerging viewpoint over recent years has been that human angioplasty restenosis is attributable to a number of processes, specifically, neointima formation, subacute recoil, and geometric remodeling...

A comparison of balloon-expandable–stent implantation with balloon angioplasty in patients with coronary artery disease
Serruys PW, de Jaegere P, Kiemeneij F, et al, for the BENESTENT Study Group

As the STRESS trial (see page 164) was being conducted, an almost identical European trial was also recruiting, and the results of both STRESS and BENESTENT were published back to back in the New England Journal of Medicine...