The supply of oxygen to the tissues and the regulation of the capillary circulation
A. Krogh

This seminal paper is the first to describe the regulation of the capillary circulation in relation to the supply of oxygen to tissues...

Regional differences in capillary permeability
H.S. Mayerson, C.G. Wolfram, H.H. Shirley Jr, K. Wasserman

This highly ingenious publication resulted in the development of the concept that capillary permeability might be regulated by pores of differing sizes...

Endothelial contraction induced by histamine-type mediators: an electron microscopic study
G. Majno, S.M. Shea, M. Leventhal

One of the important physiological functions of the microcirculation is the regulation of permeability...

Isolation of a tumor factor responsible for angiogenesis
J. Folkman, E. Merler, C. Abernathy, G. Williams

In this now legendary paper, Folkman and colleagues describe the isolation and characterization of a substance derived from tumors that promotes the growth of blood vessels...

Quantitative investigations of the adhesiveness of circulating polymorphonuclear leukocytes to blood vessel walls
A. Atherton G.V. Born

Much of today’s research into the microcirculation deals with the interactions between circulating leukocytes and the endothelium...

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
R.F. Furchgott, J.V. Zawadzki

This clearly revolutionary article set the stage for modern vascular biology...

Superoxide radicals in feline intestinal ischemia
D.N. Granger, G. Rutili, J. McCord

A major breakthrough in our understanding of the mechanisms of ischemia/reperfusion injury to the microcirculation was provided by this elegant study...

Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog
R.L. Engler, G.W. Schmid-Schonbein, R.S. Pavlec

In this paper, Engler and colleagues present the very first experimental report that the low flow or “noreflow” that occurs following myocardial ischemia/ reperfusion is mediated at least in part by leukocyte plugging in myocardial capillaries...

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1
R. Rothlein, M.L. Dustin, S.D. Marlin, T.A. Springer

Rothlein and colleagues describe the discovery and characterization of a novel leukocyte– endothelial cell adhesion molecule in this now classic paper...

Leukocyte rolling and extravasation are severely compromised in P-selectin–deficient mice
T.N. Mayadas, R.C. Johnson, H. Rayburn, R.O. Hynes, D.D. Wagner

We are treated here to a marvelous blend of cutting-edge molecular biology, cell physiology, and classic physiology in one...