The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
R.F. Furchgott, J.V. Zawadzki

This is where “EDRF” (endothelium-derived relaxing factor) began—though nowhere in the text does the term itself appear...

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
L.J. Ignarro, G.M. Buga, K.S. Wood, R.E. Byrns, G. Chaudhuri

Following the discovery of endothelium-derived relaxing factor (EDRF), the chase was on to identify it...

Vascular endothelial cells synthesize nitric oxide from L-arginine
R.M. Palmer, D.S. Ashton, S. Moncada

Palmer et al took the endothelium-derived relaxing factor (EDRF) story an important step further by establishing the metabolic precursor for nitric oxide (NO) production as L-arginine and, on the basis of its strict structural and isomeric specificity, pointed to an enzymatic step in its production...

A novel potent vasoconstrictor peptide produced by vascular endothelial cells
M. Yanagisawa, H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, T. Masaki

Once endothelium had been recognized as capable of releasing vasoactive substances, it became apparent that it might also exert vasoconstrictor effects...

Crucial role of endothelium in the vasodilator response to increased flow in vivo
U. Pohl, J. Holtz, R. Busse, E. Bassenge

The phenomenon of flow-related vasodilatation, described 50 years earlier and recently shown to be endothelium-dependent in vitro, is here confirmed as endothelium-dependent in vivo...

Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries
M. Nakashima, J.V. Mombouli, A.A. Taylor, P.M. Vanhoutte

Vanhoutte and colleagues, who have contributed much to endothelial pharmacology, here investigate endothelium-dependent hyperpolarization in human arteries...

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
P. Vallance, J. Collier, S. Moncada

This paper is the outcome of a series of three studies by Moncada: the first was one of the papers showing that endothelium-derived relaxing factor (EDRF) was nitric oxide (NO); the second was a study showing that the amino acid L-arginine was the metabolic precursor of NO; and the third described the development of nonmetabolized analogs of L-arginine...

Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
P.L. Ludmer, A.P. Selwyn, T.L. Shook, R.R. Wayne, G.H. Mudge, R.W. Alexander, P. Ganz

It was obvious from the time of Furchgott & Zawadski’s classic paper, which showed that acetylcholine induced both endothelium-dependent dilatation in the presence of healthy endothelium and direct vascular smooth muscle contraction in the case of endothelial dysfunction or loss, that acetylcholine could be a useful pharmacological tool with which to test endothelial function...

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta
R.L. Minor Jr, P.R. Myers, R. Guerra Jr, J.N. Bates, D.G. Harrison

This was the first study to show that impaired nitric oxide (NO)-mediated endotheliumdependent dilatation might be due not to reduced production but to decreased availability of reactive NO...

Different interactions of platelets with arterial and venous coronary bypass vessels
Z.H. Yang, P. Stulz, L. von Segesser, E. Bauer, M. Turina, T.F. Lüscher

Coronary artery bypass grafting has become a highly successful industry for relief of disabling angina, with benefit to life expectancy where this is reduced...