Evidence that activation of the renin-angiotensin-aldosterone system is involved in the pathophysiology of heart failure derives from a number of experimental and clinical studies. The most compelling evidence that the chronic stimulation of this system is harmful derives from experience with angiotensin-converting enzyme (ACE) inhibitors, which consistently improve both the clinical course and the ventricular dysfunction, particularly in subjects with myocardial infarction, arterial hypertension, or advanced ventricular remodeling of any etiology. The most relevant findings reported in the literature that deal with reversal of remodeling related to ACE-inhibitor therapy are discussed in this paper...