Influence of chronic captopril therapy on the infarcted left ventricle of the rat
J.M. Pfeffer, M.A. Pfeffer, E. Braunwaldd

Ligation of the left anterior descending artery of the anesthetized rat to produce a variable-sized myocardial infarction of the left ventricle, though first described by Fishbein in 1978, has become known to many as the "Pfeffer model."...

Angiotensin I converting enzyme inhibitors and cardiac remodeling
C. Van Krimpen, R.G. Schoemaker, J.P.M. Cleutjens, J.F.M. Smits, H.A.J. Struyker-Boudier, F.T. Bosman, M.J.A.P. Daemen

One of the main controversies to emerge from the mortality trials of ACE inhibition after myocardial infarction stems from the findings of CONSENSUS II (COoperative North Scandinavian ENalapril SUrvival Study II)...

Pathological hypertrophy and cardiac interstitium: fibrosis and renin-angiotensin-aldosterone system
K.T. Weber, C.G. Brilla

Cardiologists are renowned for their focus on a single organ often to the exclusion of other vital related structures...

Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the Survival and Ventricular Enlargement Trial
M.A. Pfeffer, E. Braunwald, L.A. Moyé, and the SAVE Investigators

The SAVE (Survival And Ventricular Enlargement) trial, led by Marc Pfeffer and Eugene Braunwald, represents a landmark investigation for a number of reasons...

Cells expressing angiotensin II receptors in fibrous tissue of rat heart
Y. Sun, K.T. Weber

Angiotensin II has been implicated in systemic hypertension and the death of patients with heart failure and after acute myocardial infarction...

Structural basis of end-stage failure in ischemic cardiomyopathy in humans
C.A. Beltrami, N. Finato, M. Rocco, G.A. Feruglio, C. Puricelli, E. Cigola, F. Quaini, E.H. Sonnenblick, G. Olivetti, P. Anversa

Loss of irreplaceable cardiomyocytes is a key etiological factor in the development of heart failure, irrespective of whether it is classified as being of ischemic or nonischemic origin...

Collagen remodeling after myocardial infarction in the rat heart
J.P.M. Cleutjens, M.J.A. Verluyten, J.F.M. Smits, M.J.A.P. Daemen

Within the myocardium, interstitial collagen networks are composed largely of type I and III fibrillar subtypes, which help to preserve tissue architecture and chamber geometry, while also being the major determinant of wall stiffness...

Angiotensin converting enzyme and myofibroblasts during tissue repair in the rat heart
Y. Sun, K.T. Weber

This study was designed to determine whether collagen-producing phenotypically modulated fibroblasts (myofibroblasts, myoFbs) were present following experimentally-induced myocardial infarction and following pericardectomy within the visceral pericardium as it healed by fibrosis...

Angiotensin II receptor blockade after myocardial infarction in rats: effects on hemodynamics, myocardial DNA synthesis, and interstitial collagen content
J.F.M. Smits, C. Van Krimpen, R.G. Schoemaker, J.P.M. Cleutjens, M.J.A.P. Daemen

Cardiac remodeling represents an alteration in the geometry of the heart, which may act as an adaptive or a pathological process...

Fibrosis, a common pathway to organ failure: angiotensin II and tissue repair
K.T. Weber

In an earlier review (see page 46), I commented on the role that the work of Karl Weber’s group may have had in expanding the horizons of cardiologists and cardiovascular physicians beyond cardiomyocytes, the heart, and the cardiovascular system...