Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys
J.K. Williams, G.K. Sukhova, D.M. Herrington, P. Libby

One of the most remarkable and consistent effects of cholesterol lowering, whether via ß-hydroxy-ß-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or other means, is the dramatic reduction in patient events, with little effect on plaque size...

British Cardiac Society: 125I-labelled fibrinogen, autoradiography, and stereoarteriography in identification of coronary thrombotic occlusion in fatal myocardial infarction
W.F. Fulton, D.G. Sumner

In the late 1970s and early 1980s, there was a major paradigm shift in thinking relating to the cause of myocardial infarction...

Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion
E. Falk

The seminal observations by Davies and colleagues that myocardial infarction was caused by plaque rupture and subsequent coronary thrombosis, suggested a sudden coronary event causing a defined clinical syndrome...

Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
L. Boring, J. Gosling, M. Cleary, I.F. Charo

Macrophages are important cells in the pathogenesis of atherosclerosis, with macrophages being evident in fatty streaks, one of the earliest lesions of atherosclerosis...

Compensatory enlargement of human atherosclerotic coronary arteries
S. Glagov, E. Weisenberg, C.K. Zarins, R. Stankunavicius, G.J. Kolettis

Atherosclerosis is an intimal disease, with accumulation of cells and lipid occurring in the intima...

Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content
M.J. Davies, P.D. Richardson, N. Woolf, D.R. Katz, J. Mann

Not all atherosclerotic plaques produce clinically important sequelae...

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis
M.T. Quinn, S. Parthasarathy, L.G. Fong, D. Steinberg

The major initiating event in atherosclerosis is migration of monocytes from the circulating blood into the vessel wall to form resident macrophages, with subsequent accumulation of lipid...

LInfluence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques
P.D. Richardson, M.J. Davies, G.V. Born

The demonstration that coronary occlusion is due to plaque rupture (or fissuring) paved the way for a series of studies attempting to identify the characteristics of plaques that rupture, both mechanically (this paper) and histologically...

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man
S. Yla-Herttuala, W. Palinski, M.E. Rosenfeld, S. Parthasarathy, T.E. Carew, S. Butler, J.L. Witztum, D. Steinberg

The lipid that accumulates in atherosclerosis is derived from plasma lipoproteins, particularly low-density lipoprotein (LDL)...

Plaque fissures in human coronary thrombosis
P. Constantinides

Historically, coronary thrombosis has been considered in turn to be due to stasis of blood upstream of narrowed vessel segments, a hypercoagulable state in predisposed individuals, or the hemorrhage of plaque vasa vasorum penetrating from the adventitia...