Dialogues in Cardiovascular Medicine - Vol 4 . No. 4 . 1999






The natural history of isolated left ventricular diastolic dysfunction
W.C. Brogan 3d, L.D. Hillis, E.D. Flores, R.A. Lange

Isolated left ventricular (LV) diastolic dysfunction was defined in this paper by the following criteria: (i) an elevated LV end-diastolic pressure with normal LV end-diastolic and end-systolic volumes; (ii) a normal LV ejection fraction; and (iii) no coronary artery or valvular disease...



Evaluation of left ventricular diastolic function from the pattern of left ventricular filling
W.C. Little, J.G. Warner Jr, K.M. Rankin, D.W. Kitzman, C.P. Cheng

Reviewed in this article are the left ventricular (LV) Doppler echocardiographic filling patterns and underlying physiologic mechanisms in normal hearts and those with diastolic dysfunction...



Congestive heart failure with normal left ventricular systolic function. Clinical approaches to the diagnosis and treatment of diastolic heart failure
R.S. Vasan, E.J. Benjamin, D. Levy

This article reviews the diagnosis and treatment of congestive heart failure (CHF), emphasizing the importance of diastolic heart failure or diastolic dysfunction...



Relaxation-systolic pressure relation. A load-independent assessment of left ventricular contractility
T.C. Gillebert, A.F. Leite-Moreira, S.G. De Hert

Gillebert et al set out here to review the influence of loading conditions on the decrease in left ventricular pressure (LVP) during late systole and early diastole...



Diastolic dysfunction in congestive heart failure
W. Grossman

Grossman, in his comprehensive review of diastolic dysfunction, summarizes the pathophysiological features of this syndrome...



How to diagnose diastolic heart failure
European Study Group on Diastolic Heart Failure

This report of the European Study Group on Diastolic Heart Failure proposes guidelines for the diagnosis of diastolic heart failure using well-defined cutoff values of indices of left ventricular (LV) function obtainable during cardiac catheterization or during noninvasive cardiac imaging, and summarizes existing evidence of abnormal LV relaxation, filling, and diastolic distensibility and stiffness in different cardiac diseases frequently characterized by diastolic heart failure...



Diastolic failure: pathophysiology and therapeutic implications
D.L. Brutsaert, S.U. Sys, T.C. Gillebert

Diastole and diastolic failure are defined, in this classic review, from a physiologic point of view, and a description is given of the pathophysiology of pressure- or volumeoverloaded hearts...



Left ventricular hypertrophy and impaired diastolic filling in essential hypertension. Diastolic mechanisms for systolic dysfunction during exercise
A. Cuocolo, F.L. Sax, J.E. Brush, B.J. Maron, S.L. Bacharach, R.O. Bonow

In many patients with essential hypertension, in the absence of coronary artery disease, left ventricular (LV) systolic function is normal at rest, but may respond abnormally during exercise...



Nonuniform course of left ventricular pressure fall and its regulation by load and contractile state
A.F. Leite-Moreira, T.C. Gillebert

This article reports the results of experiments examining the effect of changes in load on the course of left ventricular (LV) pressure fall...



Restrictive left ventricular filling pattern in dilated cardiomyopathy assessed by Doppler echocardiography: clinical, echocardiographic and hemodynamic correlations and prognostic implications. Heart Muscle Disease Study Group
B. Pinamonti, A. Di Lenarda, G. Sinagra, F. Camerini

In systolic heart failure, symptoms of pulmonary congestion and dyspnea on exertion are signs of concomitant diastolic failure. In fact, delayed left ventricular (LV) pressure decay affecting the diastolic pressure-volume relationship is often the first manifestation of impaired systolic function...






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