What is the most effective management
of hypertension in diabetes? |
Over half of type 2 diabetics,
particularly women, are likely to be
hypertensive at age 50 using the
recently recommended cutoff
of 130/85 mm Hg. The cause is
multifactorial and includes insulin
resistance, which is closely related
to obesity, itself a risk factor for
hypertension. The first-line
treatment is lifestyle modification
(exercise, weight loss, and smoking
withdrawal). This must almost
always be aided by drugs,
preferably a long-acting
angiotensin-converting enzyme
inhibitor on the grounds of hard
end points (cardiovascular events),
renoprotection, and quality of life
(decreased impotence), often
combined with a low-dose diuretic
or a dihydropyridine calcium channel
blocker. Proteinuria warrants
even more stringent blood pressure
control (125/75 mm Hg). Finally,
aggressive use of statins may be
beneficial even if initial cholesterol
levels are only average...
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