Effects of an intravenous infusion of a potassium-glucose-insulin
solution on the electrocardiographic signs of myocardial infarction
D. Sodi-Pallares, M.R. Testelli, B.L. Fishleder, A. Bisteni, G.A. Medrano, C. Friedland, A. De Micheli
This paper, which is a little more than a collection
of case reports, was published in
1962 and its results were largely forgotten
until the DIGAMI study (Diabetic patients
receiving Insulin-Glucose infusion during
Acute Myocardial Infarction) revealed strong evidence for
the therapeutic effect of insulin and glucose during acute
myocardial infarction...
Diabetes and cardiovascular disease. The Framingham study
W.B. Kannel, D.L. McGee
In this subset analysis from the father (or should I
say mother) of all epidemiological studies—the
Framingham study—diabetes was clearly defined
as a major cardiovascular risk factor...
Mortality from coronary heart disease and stroke in relation
to degree of glycaemia: the Whitehall study
J.H. Fuller, M.J. Shipley, G. Rose, R.J. Jarrett, H. Keen
For the first time in 1983, a study related risk of
stroke in addition to coronary heart disease to
the degree of glycemia...
Diabetes, other risk factors, and 12-yr cardiovascular mortality
for men screened in the Multiple Risk Factor Intervention Trial
J. Stamler, O. Vaccaro, J.D. Neaton, D. Wentworth
With its very large study population,
the massive Multiple Risk Factor
Intervention Trial (MRFIT) study had
great advantages over others...
NIDDM and its metabolic control predict coronary heart disease
in elderly subjects
J. Kuusisto, L. Mykkanen, K. Pyörälä, M. Laakso
Scandinavia is an ideal environment in which to
study epidemiological questions as by and large
it can boast well-documented records and people
there are relatively easy to contact and willing to
take part in studies...
Angiographic findings and outcome in diabetic patients treated
with thrombolytic therapy for acute myocardial infarction:
the GUSTO-I experience
S.L. Woodfield, C.F. Lundergan, J.S. Reiner, S.W. Greenhouse, M.A. Thompson, S.C. Rohrbeck,
Y. Deychak, M.L. Simoons, R.M. Califf, E.J. Topol, A.M. Ross
GUSTO (Global Utilization of Streptokinase
and TPA for Occluded arteries) was the first
trial that sought to determine why patients
with diabetes have approximately twice
the mortality of nondiabetic patients in the
setting of an acute myocardial infarction...
Cholesterol lowering with simvastatin improves prognosis
of diabetic patients with coronary heart disease. A subgroup
analysis of the Scandinavian Simvastatin Survival Study (4S)
K. Pyörälä, T.R. Pedersen, J. Kjekshus, O. Faergeman, A.G. Olsson, G. Thorgeirsson
Diabetic patients are subjected to an excessive
coronary heart disease risk, which is thought
to be in part explained by the adverse
effects of diabetes on serum lipids and
other general cardiovascular risk factors...
Intensive blood-glucose control with sulphonylureas or insulin
compared with conventional treatment and risk of complications
in patients with type 2 diabetes (UKPDS 33)
UK Prospective Diabetes Study (UKPDS) Group
The UK Prospective Diabetes Study (UKPDS)
was the largest and longest study in the
history of diabetes...
Tight blood pressure control and risk of macrovascular
and microvascular complications in type 2 diabetes (UKPDS 38)
UK Prospective Diabetes Study Group
Although only a subsidiary part of the main
United Kingdom Prospective Diabetes Study
(UKPDS), this study actually revealed the
more dramatic results...
Glycometabolic state at admission: important risk marker
of mortality in conventionally treated patients with diabetes
mellitus and acute myocardial infarction: long-term results from
the DIGAMI study
K. Malmberg, A. Norhammar, H. Wedel, L. Rydén
DIGAMI (Diabetic patients receiving Insulin-
Glucose infusion during Acute Myocardial
Infarction study) launched a thousand
insulin prescriptions in every Coronary Care
Unit across the world and made a large
impact on the clinical care of diabetic patients undergoing
myocardial infarction...
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