Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
M.H. Alderman, S. Madhavan, W.L. Ooi, H. Cohen, J.E. Sealey, J.H. Laragh

This was one of the first prospective human studies to suggest an important role of the renin-angiotensin system in the etiology of myocardial infarction...

Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions
S. Yusuf, C.J. Pepine, C. Garces, H. Pouleur, D. Salem, J. Kostis, C. Benedict, M. Rousseau, M. Bourassa, B. Pitt

In this article, the Studies Of Left Ventricular Dysfunction (SOLVD) trial investigators address the issue as to whether ACE inhibition reduces the risk of the development of acute coronary events in high-risk patients with low ejection fractions...

The emerging concept of vascular remodeling
G.H. Gibbons, V.J. Dzau

An accompanying review (see page 115) relates to a paper dealing with the structural and hemodynamic remodeling of the heart that follows acute myocardial infarction...

Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection
E.M. Lonn, S. Yusuf, P. Jha, T.J. Montague, K.K. Teo, C.R. Benedict, B. Pitt

Angiotensin-converting enzyme (ACE) inhibitors have found an increasing role in the management of a variety of cardiovascular disorders...

Effects of captopril on ischemic events after myocardial infarction. Results of the Survival And Ventricular Enlargement trial. SAVE Investigators
J.D. Rutherford, M.A. Pfeffer, L.A. Moye, B.R. Davis, G.C. Flaker, P.R. Kowey, G.A. Lamas, H.S. Miller, M. Packer, J.L. Rouleau, et al.

The effects of the angiotensin-converting enzyme (ACE) inhibitor captopril on total mortality after myocardial infarction (MI) was first assessed among the 2331 patients recruited to the Survival And Ventricular Enlargement (SAVE) trial, all of whom had an ejection fraction of <40% on radionuclide scanning, but no symptoms of heart failure. After a relatively long follow-up period of 42 months, a relative risk reduction of 19% was observed...

Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease
F. Diet, R.E. Pratt, G.J. Berry, N. Momose, G.H. Gibbons, V.J. Dzau

Diet et al’s descriptive histological study was designed to demonstrate how tissue angiotensin- converting enzyme (ACE) might be implicated in the atherosclerotic process...

Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease: the TREND* Study
G.B. Mancini, G.C. Henry, C. Macaya, B.J. O'Neill, A.L. Pucillo, R.G. Carere, T.J. Wargovich, H. Mudra, T.F. Lüscher, M.I. Klibaner, H.E. Haber, A.C. Uprichard, C.J. Pepine, B. Pitt

Mancini and colleagues hypothesized that angiotensin-converting enzyme (ACE) inhibitors might confer a beneficial effect on coronary ischemic events, by influencing endothelial function in favor of vasodilation...

Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators
D.E. Vaughan, J.L. Rouleau, P.M. Ridker, J.M. Arnold, F.J. Menapace, M.A. Pfeffer

Vaughan and colleagues wished to evaluate the theory that angiotensin-converting enzyme (ACE) inhibitors might have a favorable effect on fibrinolytic balance...

Indications for ACE inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials
The ACE Inhibitor Myocardial Infarction Collaborative Group

This meta-analysis summarized the data from five randomized trials—the Second COoperative North Scandinavian ENalapril SUrvival Study (CONSENSUS-II), Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico– III (GISSI-3), Fourth International Study of Infarct Survival (ISIS-4), Chinese Cardiac Study (CCS-1), and Survival of Myocardial Infarction: Long-term Evaluation (SMILE) trial—of angiotensin-converting enzyme (ACE)- inhibitor therapy started early (<36 h) in the acute phase following myocardial infarction (MI)...

Angiotensin-converting enzyme inhibitors
N.J. Brown, D.E.Vaughan

The angiotensin-converting enzyme (ACE) inhibitors collectively represent one of the major advances in cardiovascular therapeutics over the past 20 years...