Janse devoted the major part of his life in science
to the difficult task of visualizing electrical propagation
through the heart during the initiation and
maintenance of arrhythmias...
M. J. Janse, F. J. van Capelle, G. E. Freud, D. Durrer
It is well established that, following initiation of the
impulse in the sinoatrial (S-A) node, propagation
through the atrial musculature is asymmetric,
demonstrating regions of fast and slow conduction...
A subpopulation of cells with unique electrophysiological properties
in the deep subepicardium of the canine ventricle. The M cell
S. Sicouri, C. Antzelevitch
Anatomy in its purest form is regarded by
many as a done-and-dusted (if not dead)
subject...
Membrane current through adenosine-triphosphate–regulated
potassium channels in guinea-pig ventricular cells
A. Noma, T. Shibasaki
Having earlier identified a K+ current activated
when intracellular ATP levels fall (I K-ATP), in
this paper Noma and colleagues used the
whole-cell voltage clamp technic to examine
the contribution made by I K-ATP to the
whole-cell current generated by adenosine triphosphate
(ATP) depletion in ventricular cells...
Early afterdepolarizations: mechanism of induction and block.
A role for L-type Ca2+ current
C. T. January, J. M. Riddle
This is a very useful paper in my opinion, but
for reasons that may not have been initially
intended by the authors...
The Sicilian gambit. A new approach to the classification of
antiarrhythmic drugs based on their actions on arrhythmogenic
mechanisms
Task Force of the Working Group on Arrhythmias of the European Society of Cardiology
The Vaughan–Williams classification (VWC) of
antiarrhythmic drugs was believed by some in
the late 1980s to have outlived its usefulness...
Molecular determinants of state-dependent block of
Na+ channels by local anesthetics
D. S. Ragsdale, J. C. McPhee, T. Scheuer, W. A. Catterall
In this study, it was shown that, by altering the structure
of rat brain Na+ channels (by site-directed
mutagenesis), it was possible to selectively alter the
binding of local anesthetics to the rested, open, and
inactivated states of the channel, and the ability of
drugs to access their binding site via a hydrophilic pathway...
Two long QT syndrome loci map to chromosomes 3 and 7
with evidence for further heterogeneity
C. Jiang, D. Atkinson, J. A. Towbin, I. Splawski, M. H. Lehmann, H. Li, K. Timothy,
R. T. Taggart, P. J. Schwartz, G. M. Vincent, et al
In this paper, the authors took several generations
of 15 families, all with long QT syndrome (LQT),
classified individual family members as being
symptomatic (expressing arrhythmias) or not, and
related this to genotype using polymerase chain
reaction (PCR) analysis...
Molecular mechanism for an inherited cardiac arrhythmia
P. B. Bennett, K. Yazawa, N. Makita, A. L. George
This article describes single-channel behavior
of mutant Na+ channels from human hearts
associated with one form of hereditary long QT
syndrome (LQT3)...
The structure of the potassium channel: molecular basis of
K+ conduction and selectivity
D. A. Doyle, J. Morais Cabral, R. A. Pfuetzner, A. Kuo, J. M. Gulbis,
S. L. Cohen, B. T. Chait, R. MacKinnon
This is a truly excellent paper, not simply because
it changed the way we think about ion channel
function, but because it set out to disprove a
hypothesis (the most valuable scientific approach,
in my view), and succeeded unequivocally...
A randomized trial of propranolol in patients with
acute myocardial infarction. I. Mortality results
ß-Blocker Heart Attack Research Group
From a drug developmental point of view, this paper
reaches back into the past, yet still has a very
contemporary context, so I have saved it till last...
|
