Experimental studies of physical fitness in relation to age
S. Robinson

Although it was well recognized that older individuals have reduced exercise tolerance, this exhaustive work from the Harvard Fatigue Laboratory quantitatively sorted out the relative contributions of the cardiac, pulmonary, and hematological systems...

The effect of age on contractile protein ATPase activity and the velocity of shortening
N. R. Alpert, H. H. Gale, N. Taylor. In: Tanz RD, Kavaler F, Roberts J, eds.

While age-associated changes in physiology were being studied in a variety of species, Albert et al set out to explore both possible biochemical and mechanical alterations at the myocyte level...

Reduction in maximal oxygen uptake with age
I. Astrand, P. O. Astrand, I. Hallback, A. Kilbom

One of the greatest challenges in the field of aging research is to distinguish those physiologic changes that are due to normal aging from those changes influenced by lifestyle, disease, diet, exercise, and environmental factors...

Diminished inotropic response of aged myocardium to catecholamines
E. G. Lakatta, G. Gerstenblith, C. S. Angell, N. W. Shock, M. L. Weisfeldt

Independent laboratory work and clinical observations in humans and animals consistently report a decrease in the cardiovascular responsiveness to stress with increasing age...

Decrease in the rate of RNA and protein synthesis and degradation in the myocardium under long-term compensatory hyperfunction and on aging
F. Z. Meerson, M. P. Javich, M. I. Lerman

In the mid 1950s, Sir W. Pickering, in referring to the similarities between long-standing hypertension and aging, likened aging to “muted hypertension” and hypertension to “accelerated aging.”..

Effect of age on the response of the left ventricular ejection fraction to exercise
S. Port, F. R. Cobb, R. E. Coleman, R. H. Jones

A dilemma developed in how to apply the building body of evidence from laboratory studies regarding age-related cardiovascular changes to the clinical arena...

Role of aortic input impedance in the decreased cardiovascular response to exercise with aging in dogs
F. C. Yin, M. L. Weisfeldt, W. R. Milnor

Around the same time Port and coworkers were pursuing the impact of age and myocardial contractile reserve on decreased exercise performance, Yin et al focused their attention on the possible contribution of increased afterload...

Intracellular calcium transients and developed tension in rat heart muscle. A mechanism for the negative interval–strength relationship
C. H. Orchard, E. G. Lakatta

One of the hallmarks of cardiovascular aging is prolonged myocyte contraction, which leads to delayed early diastolic filling...

Age-associated changes in beta-adrenergic modulation on rat cardiac excitation–contraction coupling
R. P. Xiao, H. A. Spurgeon, F. O'Connor, E. G. Lakatta

Age-associated decrease in cardiovascular responsiveness to ß-adrenergic stimulation (ßAS) is characterized by a decrease in heart rate (HR) augmentation, left ventricular dilatation, and a decrease in contractility during exercise...

Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women
J. L. Fleg, F. O’Connor, G. Gerstenblith, L. C. Becker, J. Chulow, S. P. Schulman, E. G. Lakatta

The effort to understand why older individuals have a decreased exercise capacity continues...