Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin
M. Rocha e Silva, W. T. Beraldo, G. Rosenfeld

In the groundbreaking experiments on the actions of snake venoms described in this paper, the authors observed, for the venom of concern to us here, ie, Bothrops jararaca, that blood from dogs that had received minute doses of the venom had a strong stimulating effect on the isolated guinea-pig gut, as well as on other organs containing smooth muscle, like the uterus. Systemically, it was hypotensive...

Role of endothelial cells in relaxation of isolated arteries by bradykinin
P. D. Cherry, R. F. Furchgott, J. V. Zawadzki, D. Jothianandan

The perplexing differences in the response to bradykinin of intestinal and uterine smooth muscle on the one hand (stimulation), and vascular smooth muscle on the other hand (relaxation), was at long last clearly explained by the experiments described in this now classic paper...

Why are converting enzyme inhibitors vasodilators?
P. M. Vanhoutte, W. Auch-Schwelk, M. L. Biondi, R. Lorenz, B. Schini, M. J. Vidal

In 1989, the angiotensin-converting enzyme inhibitors (ACEIs) were already recognized as an important drug class in the treatment of hypertension and heart failure...

Kinins and endothelium-dependent relaxations to converting enzyme inhibitors in perfused canine arteries
J. V. Mombouli, P. M. Vanhoutte

Investigations into the differences between the various angiotensin-converting enzyme (ACE) inhibitors in animal experiments using isolated aortic ring preparations have shown that an additional effect to the primary one may be present...

Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors
J. V. Mombouli, S. Illiano, T. Nagao, T. Scott-Burden, P. M. Vanhoutte

This series of remarkable experiments was designed to analyze the mechanisms involved in the potentiation of endothelium-dependent relaxations caused by the inhibition of angiotensin- converting enzyme (ACE)...

Kinins mediate kallikrein-induced endothelium-dependent relaxations in isolated canine coronary arteries
J. V. Mombouli, P. M. Vanhoutte

The angiotensin-converting enzyme (ACE) both mediates the conversion of angiotensin I into angiotensin II and inactivates bradykinin through a proteolytic mechanism...

Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries
M. Nakashima, J. V. Mombouli, A. A. Taylor, P. M. Vanhoutte

Endothelium-dependent relaxation of vascular smooth muscle, induced by shear stress or acetylcholine, is mediated mainly by nitric oxide (NO)...

Role of endogenous bradykinin in human coronary vasomotor control
P. Groves, S. Kurz, H. Just, H. Drexler

Animal experiments have been extensively used to study the role of bradykinin in endothelium- dependent vasodilation...

Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting enzyme inhibition
A. Prasad, S. Husain, A. A. Quyyumi

Potentiation of endothelium-mediated vasorelaxation by angiotensin-converting enzyme (ACE) inhibition has been demonstrated in animal experiments in various species, as well as in humans...

Contribution of bradykinin receptor dysfunction to abnormal coronary vasomotion in humans
A. Prasad, S. Husain, W. Schenke, R. Mincemoyer, N. Epstein, A. A. Quyyumi

Based on findings from diagnostic cardiac catheterization and coronary angiography, Prasad and colleagues carried out a systematic study of endothelium-mediated responses of the large epicardial coronary arteries and resistance vessels in patients with coronary artery disease...