Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction
M. A. DeWood, J. Spores, R. Notske, L. T. Mouser, R. Burroughs, M. S. Golden, H. T. Lang

When published in 1980, this study represented the largest experience gained with coronary angiography performed during the very acute phase of an evolving ST-segment elevation myocardial infarction...

Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction
ISIS-2 (Second International Study of Infarct Survival) Collaborative Group

The Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto miocardico (GISSI) and Second International Study of Infarct Survival (ISIS-2) trials were two landmark trials that were decisive for the worldwide introduction of thrombolysis as standard therapy for acute myocardial infarction...

Collaborative overview of randomised trials of antiplatelet therapy—I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
Antiplatelet Trialists’ Collaboration

The extensive collaborative overview carried out by R. Collins, R. Peto, and C. Baigent from Oxford, and by P. Sandercock, D. Dunbalin, and C. Warlow from Edinburgh had a major impact on the use of antiplatelet therapy worldwide, mainly of aspirin...

A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease (ESSENCE)
M. Cohen, C. Demers, E. P. Gurfinkel, A. G. Turpie, G. J. Fromell, S. Goodman, A. Langer, R. M. Califf, K. A. Fox, J. Premmereur, F. Bigonzi, J. Stephens, B. Weatherley, and the Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study Group (ESSENCE)

The ESSENCE (Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-wave Coronary Events) Study Group directly compared enoxaparin with unfractionated heparin in 3171 patients with a non–ST-segment elevation acute coronary syndrome...

Aspirin, heparin, or both to treat acute unstable angina
P. Theroux, H. Ouimet, J. McCans, J. G. Latour, P. Joly, G. Lévy, E. Pelletier, M. Juneau, J. Staziak, P. deGuise, G. B. Pelletier, D. Rinzler, D.D. Waters

Patients with unstable angina were included in this randomized, double-blind, 22 factorial trial to study the usefulness of aspirin, heparin, and their combination...

The prognostic value of serum troponin T in unstable angina
C. W. Hamm, J. Ravkilde, W. Gerhardt, P. Jorgensen, E. Peheim, L. Ljungdahl, B. Goldmann, H. A. Katus

This seminal paper was the first to describe the diagnostic value of troponin T in patients with unstable angina...

Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty
The EPIC Investigators

EPIC (Evaluation of IIb/IIIa platelet receptor antagonist 7E3 in Preventing Ischemic Complications) was the first large-scale placebo-controlled trial ever performed with a glycoprotein (GP) IIb/IIIa receptor antagonist (the monoclonal antibody abciximab)...

Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators
C. W. Hamm, C. Heeschen, B. Goldmann, A. Vahanian, J. Adgey, C. M. Miguel, W. Rutsch, J. Berger, J. Kootstra, M. L. Simoons

The study tested the hypothesis that abciximab will be particularly effective in patients with elevated troponin T levels, a surrogate marker of thrombus formation, because of the properties of the glycoprotein (GP) IIb/IIa receptor antagonist to block platelet aggregate formation...

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
S. Yusuf, F. Zhao, S. R. Mehta, S. Chrolavicius, G. Tognoni, K. K. Fox

CURE (Clopidogrel in Unstable angina to prevent Recurrent Events) is a randomized double- blind trial comparing the combination of clopidogrel and aspirin with aspirin alone among 12 562 patients with a non–ST-segment elevation acute coronary syndrome (ACS)...

Multiple complex coronary plaques in patients with acute myocardial infarction
J. A. Goldstein, D. Demetriou, C. L. Grines, M. Pica, M. Shoukfeh, W. W. O'Neill

This study shares analogies with the one by DeWood et al previously discussed. Both studies were descriptive of angiographic findings obtained in small series of patients with ST-segment elevation myocardial infarction...