Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium?
J. Leor , M. Patterson, M. J. Quinones, L. H. Kedes, R. A. Kloner

Leor and colleagues, in this study, demonstrate the feasibility of rat fetal and human myocardial tissue transplantation into the infarcted adult rat myocardium...

Skeletal myoblast transplantation for repair of myocardial necrosis
C. E. Murry, R. W. Wiseman, S. M. Schwartz, S. D. Hauschka

This is the first manuscript to demonstrate that skeletal myoblasts can develop into muscle tissue when grafted into injured rat heart...

Regenerating functional myocardium: improved performance after skeletal myoblast transplantation
D. A. Taylor, B. Z. Atkins, P. Hungspreugs, T. R. Jones, M. C. Reedy, K. A. Hutcheson, D. D. Glower, W. E. Kraus

This is one of the first papers demonstrating that, in intact animals, chronic improvement in systolic and diastolic myocardial performance can be obtained by transplanting autologous skeletal myoblasts into the infarcted myocardium...

Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction
P. Menasché, A. A. Hagège, J. T. Vilquin, M. Desnos, E. Abergel , B. Pouzet, A. Bel, S. Sarateanu, M. Scorsin, K. Schwartz, et al

In this phase 1 clinical trial, the authors highlight the feasibility of autologous skeletal myoblast transplantation in ischemic cardiomyopathy while warning of possible arrhythmias arising in the transplanted hearts...

Myocyte renewal and ventricular remodelling
P. Anversa, B. Nadal-Ginard

Cardiomyocytes are thought to be terminally differentiated cells, implying that hypertrophy is the only available form of growth...

Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
A. A. Kocher, M. D. Schuster, M. J. Szabolcs, S. Takuma, D. Burkhoff, J. Wang, S. Homma, N. M. Edwards, S. Itescu

As shown by this experiment, cytokine-mobilized autologous bone marrow–derived angioblast transplantation has the potential to neovascularize the infarcted myocardium as a means of reducing ventricular remodeling...

Pluripotency of mesenchymal stem cells derived from adult marrow
Y. Jiang, B .N. Jahagirdar, R. L. Reinhardt, R. E. Schwartz, C. D. Keene, X. R. Ortiz-Gonzalez, M. Reyes, T. Lenvik, T. Lund, M. Blackstad, et al

Cells present within murine or rat adult bone marrow are capable of differentiation into cell types representing all three germ layers...

Can stem cells cross lineage boundaries?
D. J. Anderson, F. H. Gage, I. L. Weissman

Anderson and colleagues, in this well-structured commentary, address the apparent phenomenon of transdifferentiation and propose that many of the manuscripts reporting such phenomena have technical shortcomings that cloud their interpretation of data and conclusions...

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
B. Assmus, V. Schachinger, C. Teupe, M. Britten, R. Lehmann, N. Dobert, F. Grunwald, A. Aicher, C. Urbich, H. Martin, et al

Although relatively small, this is the largest and most comprehensive study of its kind!...

Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure
E. C. Perin, H. F. Dohmann, R. Borojevic, S. A. Silva, A. L. Sousa, C. T. Mesquita, M. I. Rossi, A. C. Carvalho, H. S. Dutra, H. J. Dohmann, et al

This open-label, prospective, nonrandomized study investigated the contribution of transendocardial injections of autologous bone marrow mononuclear cells (ABMMNCs) to neovascularization...