Auricular fibrillation and its relationship to clinical
irregularity of the heart
T. Lewis
The first electrocardiographic recording of atrial
fibrillation was made by Einthoven in 1906,
but a significant background noise precluded
the identification of atrial activity, although
normal ventricular complexes were seen...
Auricular fibrillation without other evidence of heart disease:
a cause of reversible heart failure
E. Phillips, S. A. Levine
Atrial fibrillation was first described in the association
with congestive heart failure, but it
was less commonly appreciated that it could
be a cause and not only a consequence of
severe left ventricular dysfunction...
Atrial fibrillation as a self-sustaining arrhythmia independent
of focal discharge
G. K. Moe, J. A. Abildskov
Since atrial fibrillatory activity on the electrocardiogram
was linked to auricular fibrillation, there
has always been a debate as to which mechanisms
operate in sustaining atrial fibrillation: a single
focus, multiple foci, or a fixed reentrant circuit...
Electrical reversion of cardiac arrhythmias.
Thomas Lewis Lecture
B. Lown
It is now 40 years since the introduction of electrical
cardioversion for cardiac tachyarrhythmias...
Epidemiologic features of chronic atrial fibrillation:
the Framingham study
W. B. Kannel, R. D. Abbott, D. D. Savage, P. M. MacNamara
The Framingham Study was the landmark study
to appreciate the epidemiological significance
of atrial fibrillation and to introduce the concept
of risk factors for the arrhythmia...
Risk factors for stroke and efficacy of antithrombotic therapy in
atrial fibrillation. Analysis of pooled data from five randomized
controlled trials
Atrial Fibrillation Investigators
Absence of organized mechanical contraction
of fibrillating atria with a consequent increase
in atrial pressure and atrial stretch and dilation
due to multiple pathophysiological
mechanisms compensating for reduced cardiac
output create conditions for blood stasis...
Atrial fibrillation begets atrial fibrillation.
A study in awake chronically instrumented goats
M. C. Wijffels, C. J. Kirchhof, R. Dorland, M. A. Allessie
Paroxysmal atrial fibrillation is a recurring disease:
the first attack will not be the last in over
90% of patients. It also tends to progress to a
permanent form over time, the transition rate
varying considerably with the etiology...
Spontaneous initiation of atrial fibrillation by ectopic beats
originating in the pulmonary veins
M. Haissaguerre, P. Jais, D. C. Shah, A. Takahashi, M. Hocini, G. Quiniou, S. Garrigue,
A. Le Mouroux, P. Le Metayer, J. Clementy
For the best part of the last century, Moe’s multiple
wavelet reentry hypothesis prevailed in our
understanding of the mechanism of sustained
atrial fibrillation...
Atrioverter: an implantable device for the treatment
of atrial fibrillation
H. J. Wellens, C. P. Lau, B. Luderitz, M. Akhbar, A. L. Waldo, A. J. Camm, C. Timmermans,
H. F. Tse, W. Jung, L. Jordaens, G. Ayers
The demand for effective therapeutic strategies
for atrial fibrillation has always been high and
is anticipated to further increase...
A comparison of rate control and rhythm control in patients
with atrial fibrillation
D. G. Wyse, A. L. Waldo, J.P. DiMarco, M. J. Domanski, Y. Rosenberg, E. B. Schron, J. C. Kellen,
H. L. Greene, M. C. Mickey, J. E. Dalquist, S. D. Corley; Atrial Fibrillation Follow-Up Investigation of
Rhythm Management (AFFIRM) Investigators
There are two main approaches to the management
of atrial fibrillation: the first, most often
pursued in patients with new-onset and persistent
atrial fibrillation, is rhythm control
aimed at restoration and maintenance of sinus
rhythm; the second is to minimize symptoms by merely
administering agents blocking the atrioventricular node...
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