Plants and the Heart
Windfalls from the opium poppy:
the discovery of papaverine and verapamil |
The discovery and development
of modern medicines from
plants is not usually a straightforward
process. Scientists
believe that the correct way to discover
a new remedy is by knowing the mechanism
of action of a plant compound
and matching it with the biochemical
basis of the disease process. However,
it is not usually like that. Careful observation
by itself can yield dividends.
For example, the antihypertensive action
of reserpine was found when psychiatric
patients, being treated with
Rauvolfia serpentina, had their blood
pressure measured as a routine. Academic
biochemical research led to
the discovery of lidocaine...
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