Reperfusion: The "21st-century turf wars" |
It was not until the second half of the 20th century that anything other than
palliative treatment could be offered to patients suffering from various pathologies
(such as atherosclerosis and myocardial infarction) that resulted in compromised
coronary flow and consequent myocardial ischemia. If the ischemia and the
affected tissue mass were sufficiently great, then mortality figures were high, usually
as a consequence of contractile failure or lethal arrhythmias. However, during the
second half of the 20th century, four independent and very different streams of research
were initiated and would culminate in the
ability, by a variety of means, to reperfuse the
ischemic human heart, with the attendant
reduction in mortality. These remarkable and
differing reperfusion technologies also lead to
cardiological “turf wars” aimed in part at winning
the hearts and revenue of the millions of
patients suffering from ischemic heart disease...
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