The theme common to the previous Trails of Discovery essays1,2 has been to identify specific scientists whose research was fundamental to the introduction of novel cardiovascular drugs into clinical practice. A subsidiary theme has been to examine the contribution of academic and industrial research collaboration to such advances, suggesting perhaps that the current vogue of “translational medicine” has a longer history than is currently recognized. This essay summarizes the events leading to the discovery and development of aldosterone antagonists and their evolution over the subsequent 50 years of research...